以前の成果はresearchmapをご覧ください。
Dr. Hiromu Ito - https://researchmap.jp/hiromuito/
Dr. Ikuo Nakanishi - https://researchmap.jp/ikuo/

原著論文/Original Papers
  1. Title
    Hiromu Ito,* Yoshimi Shoji, Ken-ichiro Matsumoto, Kiyoshi Fukuhara,* and Ikuo Nakanishi*
    Redox Biochem. Chem., in contribution.
    DOI:
    PMID:
    Released on
  2. Title
    Megumi Ueno, Minako Nyui, Ken-ichiro Matsumoto,* Ikuo Nakanishi, Hiroko P. Indo,* Akira Fujii, Masanobu Nagano, Jitbanjong Tangpong, Hideyuki J. Majima*
    J. Nutr. Sci., in contribution.
    DOI:
    PMID:
    Released on
  3. Construction of a Screening System for Lipid-Derived Radical Inhibitors and Validation of Hit Compounds to Target Retinal and Cerebrovascular Diseases
    Ryota Mori, Masami Abe, Yuma Saimoto, Saki Shinto, Sara Jodai, Manami Tomomatsu, Kaho Tazoe, Minato Ishida, Masataka Enoki, Nao Kato, Tomohiro Yamashita, Yuki Itabashi, Ikuo Nakanishi, Kei Ohkubo, Sachiko Kaidzu, Masaki Tanito, Yuta Matsuoka, Kazushi Morimoto, and Ken-ichi Yamada*
    Redox Biol., 73, 103186 (2024). Open access
    DOI: 10.1016/j.redox.2024.103186
    PMID: 38744193
    Released on May 8, 2024
  4. Scandium Ion-Promoted Electron-Transfer Disproportionation of 2-Phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl 3-Oxide (PTIO center dot) in Acetonitrile and Its Regeneration Induced by Water
    Yoshimi Shoji, Yuri Terashima, Kei Ohkubo, Hiromu Ito, Kouichi Maruyama, Shunichi Fukuzumi, and Ikuo Nakanishi*
    Int. J. Mol. Sci., 25 (8), 4417 (2024). Open access
    DOI: 10.3390/ijms25084417
    PMID: 38674002
    Released on April 17, 2024
    IJSM2024_25_4417
  5. Reactive Oxygen Species Induced by Indomethacin Enhance Accumulation of Heme Carrier Protein 1 and Hematoporphyrin Accumulation In Vitro and In Vivo in a Brain Tumor Model
    Hidehiro Kohzuki, Hiromu Ito, Hiromi Kurokawa, Hirofumi Matsui,* Tetsuya Yamamoto, and Eiichi Ishikawa
    J. Clin. Biochem. Nutr., 74 (3), 207-212 (2024) Open access
    DOI: 10.3164/jcbn.23-20
    PMID:
    Released on February 1, 2024
  6. Mitochondria Play Essential Roles in Intracellular Protection against Oxidative Stress—Which Molecules among the ROS Generated in the Mitochondria Can Escape the Mitochondria and Contribute to Signal Activation in Cytosol?
    Daisuke Masuda, Ikuo Nakanishi,* Kei Ohkubo, Hiromu Ito, Ken-ichiro Matsumoto, Hiroshi Ichikawa, Moragot Chatatikun, Wiyada Kwanhian Klangbud, Manas Kotepui, Motoki Imai, Fumitaka Kawakami, Makoto Kubo, Hirofumi Matsui, Jitbanjong Tangpong, Takafumi Ichikawa, Toshihiko Ozawa, Hsui-Chuan Yen, Daret K. St Clair, Hiroko P. Indo,* and Hideyuki J. Majima*
    Biomolecules, 14 (1), 128 (2024). Open access
    DOI: 10.3390/biom14010128
    PMID: 38275757
    Released on January 19, 2024
  7. Hair Follicle Damage after 100 mGy Low-Dose Fractionated X-ray Irradiation and the Protective Effects of TEMPOL, a Stable Nitroxide Radical, against Radiation
    Yoshihiro Kawabata, Tomoko Fukushige, Hiroko P. Indo, Ken-ichiro Matsumoto,* Megumi Ueno, Ikuo Nakanishi, Moragot Chatatikun, Wiyada Kwanhian Klangbud, Sirirat Surinkaew, Jitbanjong Tangpong, Takuro Kanekura, and Hideyuki J. Majima*
    Radiat. Res., 201 (2), 115-125 (2024).
    DOI: 10.1667/RADE-23-00167.1
    PMID: 38211765
    Released on January 12, 2024
  8. Enhanced Inhibition of Cancer Cell Migration by a Planar Catechin Analog
    Hiromu Ito,* Yoshimi Shoji, Ken-ichiro Matsumoto, Kiyoshi Fukuhara,* and Ikuo Nakanishi*
    ACS Med. Chem. Lett., 15 (2), 310-313 (2024).
    DOI: 10.1021/acsmedchemlett.3c00499
    PMID: 38352823
    Released on January 10, 2024
    images_medium_ml3c00499_0003s
  9. Photodynamic Therapy for X-ray-Induced Radiation-Resistant Cancer Cells
    Hiromu Ito,* Yoshimi Shoji, Megumi Ueno, Ken-ichiro Matsumoto, and Ikuo Nakanishi*
    Pharmaceutics, 15 (11), 2536 (2023). Open access
    DOI: 10.3390/pharmaceutics15112536
    PMID: 38004516
    Released on October 26, 2023
    pharmaceutics-15-02536-ag_s
  10. Enhancement of Cytotoxic Effects with ALA-PDT on Treatment of Radioresistant Cancer Cells
    Takafumi Ikeda, Hiromi Kurokawa,* Hiromu Ito,* Kiichiro Tsuchiya, and Hirofumi Matsui*
    J. Clin. Biochem. Nutr., 74 (1), 17-21 (2024). Open access
    DOI: 10.3164/jcbn.23-79
    PMID: 38292126
    Released on October 3, 2023
  11. Anti-Cancer Effect of a Planar Catechin Analog through the Decrease in Mitochondrial Membrane Potential
    Hiromu Ito,* Yoshimi Shoji, Ken-ichiro Matsumoto, Kiyoshi Fukuhara,* and Ikuo Nakanishi*
    ACS Med. Chem. Lett., 14 (10), 1478-1481 (2023).
    DOI: 10.1021/acsmedchemlett.3c00328
    PMID: 37849552
    Released on October 3, 2023
    images_large_ml3c00328_0004_480
  12. Water-Induced Regeneration of a 2,2-Diphenyl-1-picrylhydrazyl Radical after Its Scandium Ion-Promoted Electron-Transfer Disproportionation in an Aprotic Medium
    Ikuo Nakanishi,* Yoshimi Shoji, Kei Ohkubo,* Hiromu Ito, and Shunichi Fukuzumi*
    Molecules, 28 (13), 5002 (2023). Open access
    DOI: 10.3390/molecules28135002
    PMID: 37446663
    Released on June 26, 2023
    GA_v2_
  13. In Vitro Radical-Scavenging Mechanism of Melatonin and Its In Vivo Protective Effect against Radiation-Induced Lipid Peroxidation
    Kailash Manda,* Kei Ohkubo,* Yoshimi Shoji, A. K. M. Raushan Kabir Zoardar, Masato Kamibayashi, Toshihiko Ozawa, Kazunori Anzai, and Ikuo Nakanishi*
    Redox Biochem. Chem., 3-4, 100003 (2023). Open access
    DOI: 10.1016/j.rbc.2023.100003
    Released on April 11, 2023
  14. Effects of X-ray Irradiation on the Redox Status of Mouse Colorectal Tissues
    Megumi Ueno, Raj Kumar Parajuri, Hiromu Ito, Megumi Iiyama, Saaya Suzuki, Ken-ichiro Matsumoto,* Ikuo Nakanishi, Ichio Aoki, and Akira Sumiyoshi
    Adv. Redox Res., 8, 100067 (2023). Open access
    DOI: 10.1016/j.arres.2023.100067
    Released on March 26, 2023
  15. Evidence of Nrf2/Keap1 Signaling Regulation by Mitochondria-Generated Reactive Oxygen Species in RGK1 Cells
    Hiroko P. Indo,* Daisuke Masuda, Sompong Srburee, Hiromu Ito, Ikuo Nakanishi, Ken-ichiro Matsumoto, Samlee Mankhetkorn, Moragot Chatatikun, Sirirat Surinkaew, Lunla Udomwech, Fumitaka Kawami, Takafumi Ichikawa, Hirofumi Matsui, Jitbanjong Tangpong, and Hideyuki J. Majima*
    Biomolecules, 13 (3), 445 (2023). Open access
    DOI: 10.3390/biom13030445
    PMID: 36979380
    Released on February 27, 2023
    biomolecules-13-00445-ag_s
  16. DTPA-Bound Planar Catechin with Potent Antioxidant Activity Triggered by Fe3+ Coordination
    Kiyoshi Fukuhara,* Ikuo Nakanishi, Kohei Imai, Mirei Mizuno, Ken-ichiro Matsumoto, and Akiko Ohno
    Antioxidants, 12 (2), 225 (2023). Open access
    DOI: 10.3390/antiox12020225
    PMID: 36829782
    Released on January 18, 2023
    antioxidants-12-00225-ag-480
  17. Effects of Selenium Deficiency on Biological Results of X-ray and Carbon-Ion Beam Irradiation in Mice
    Megumi Ueno, Sayaka Shibata, Ikuo Nakanishi, Ichio Aoki, Ken-ichi Yamada, and Ken-ichiro Matsumoto*
    J. Clin. Biochem. Nutr., 72 (2), 107-116 (2023). Open access
    DOI: 10.3164/jcbn.22-57
    PMID: 36936873
    Released on December 8, 2022
  18. Acetic Acid Enhances the Effect of Photodynamic Therapy in Gastric Cancer Cells via the Production of Reactive Oxygen Species
    Hiromi Kurokawa, Hiromu Ito, Daisuke Matano, Masahiko Terasaki, and Hirofumi Matsui*
    J. Clin. Biochem. Nutr., 71 (3) 206-211 (2022). Open access
    DOI: 10.3164/jcbn.22-34
    PMID: 36447491
    Released on August 4, 2022
  19. Importance of Locations of Iron Ions to Elicit Cytotoxicity Induced by a Fenton-Type Reaction
    Kintaro Igarashi, Yoshimi Shoji, Emiko Sekine-Suzuki, Megumi Ueno, Ken-ichiro Matsumoto,* Ikuo Nakanishi, and Koji Fukui
    Cancers, 14 (15), 3642 (2022). Open access
    DOI: 10.3390/cancers14153642
    PMID: 35892902
    Released on July 27, 2022
  20. Effect of Magnesium Ion on the Radical-Scavenging Rate of Pterostilbene in an Aprotic Medium: Mechanistic Insight into the Antioxidative Reaction of Pterostilbene
    Ikuo Nakanishi,* Yoshimi Shoji, Kei Ohkubo,* Megumi Ueno, Kei Shimoda, Ken-ichiro Matsumoto, Kiyoshi Fukuhara,* and Hiroki Hamada*
    Antioxidants, 11 (2), 340 (2022). Open access
    DOI: 10.3390/antiox11020340
    PMID: 35204222
    Released on February 9, 2022
    antioxidants-11-00340-ag_s
  21. Estimation of the Local Concentration of the Markedly Dense Hydroxyl Radical Generation Induced by X-rays in Water
    Ken-ichiro Matsumoto,* Megumi Ueno, Yoshimi Shoji, and Ikuo Nakanishi
    Molecules, 27 (3), 592 (2022). Open access
    DOI: 10.3390/molecules27030592
    PMID: 35163857
    Released on January 18, 2022
  22. Simplifying Quantitative Measurement of Free Radical Species Using an X-Band EPR Spectrometer
    Yusuke Makino, Megumi Ueno, Yoshimi Shoji, Minako Nyui, Ikuo Nakanishi, Koji Fukui, and Ken-ichiro Matsumoto*
    J. Clin. Biochem. Nutr., 70 (3), 213-221 (2022). Open access
    DOI: 10.3164/jcbn.21-83
    PMID: 35692674
    Released on December 25, 2021
  23. Electrochemical Redox Behavior of 2,2-Diphenyl-1-picrylhydrazyl Radical Solubilized by beta-Cyclodextrin in Water
    Ikuo Nakanishi* and Yoshimi Shoji
    Electrochem. Commun., 134, 107190 (2022). Open access
    DOI: 10.1016/j.elecom.2021.107190
    Released on December 24, 2021
  24. Tunneling in the Hydrogen-Transfer Reaction from a Vitamin E Analog to an Inclusion Complex of 2,2-Diphenyl-1-picrylhydrazyl Radical with beta-Cyclodextrin in an Aqueous Buffer Solution at Ambient Temperature
    Ikuo Nakanishi,* Yoshimi Shoji, Kei Ohkubo,* and Shunichi Fukuzumi*
    Antioxidants, 10 (12), 1966 (2021). Open access
    DOI: 10.3390/antiox10121966
    PMID: 34943069
    Released on December 8, 2021
  25. Effects of Loading a Magnetic Field Longitudinal to the LInear Particle-Beam Track on Yields of Reactive Oxygen Species in Water
    Ken-ichiro Matsumoto,* Ikuo Nakanishi, Yasushi Abe, Shinji Sato, Ryosuke Kohno, Dousatsu Sakata, Kota Mizushima, Sung Hyun Lee, and Taku Inaniwa
    Free Radical Res., 55 (5), 547-555 (2021). Open access
    DOI: 10.1080/10715762.2021.1970151
    PMID: 34569399
    Released on September 27, 2021
  26. Effects of LET on Oxygen-Dependent and -Independent Generation of Hydrogen Peroxide in Water Irradiated by Carbon-Ion Beams
    Ken-ichiro Matsumoto,* Megumi Ueno, Minako Nyui, Yoshimi Shoji, and Ikuo Nakanishi
    Free Radical Res., 55 (6), 589-594 (2021). Open access
    DOI: 10.1080/10715762.2021.1915489
    PMID: 34519601
    Released on September 14, 2021
  27. Nitroxyl Radical as a Theranostic Contrast Agent in Magnetic Resonance Imaging
    Ken-ichiro Matsumoto,* Ikuo Nakanishi, Zhivko Zhelev, Rumiana Bakalova, and Ichio Aoki
    Antioxid. Redox Signaling, 36 (1-3), 95-121 (2022). Open access
    DOI: 10.1089/ars.2021.0110
    PMID: 34148403
    Released on June 19, 2021
  28. Protective Effects of Amino Acids on Plasmid DNA Damage Induced by Therapeutic Carbon Ions
    Katsunori Yogo,* Chieko Murayama, Ryoichi Hirayama, Ken-ichiro Matsumoto, Ikuo Nakanishi, Hiromichi Ishiyama, and Hiroshi Yasuda
    Radiat. Res., 196 (2), 197-203 (2021).
    DOI: 10.1667/RADE-21-00033.1
    PMID: 34043797
    Released on May 27, 2021

総説/Reviews
  1. On 'Spin Trapping of Superoxide and Hydroxyl Radical: Practical Aspect' by Eli Finkelstein, Gerald M. Rosen and Elmer J. Rauckman
    Toshihiko Ozawa* and Ikuo Nakanishi
    Arch. Biochem. Biophys., 726, 109191 (2022).
    DOI: 10.1016/j.abb.2022.109191
    PMID: 35318035
    Released on March 19, 2022

プロシーディングなど/Proceedings, etc.
  1. 放射線障害予防と酸化ストレス
    松本謙一郎,中西郁夫,伊藤 紘
    酸化ストレスの医学 改訂第3版, 500-506 (2024).
    Released on June 5, 2024
  2. Radiation Damage and Oxidative Stress
    Ken-ichiro Matsumoto, Ikuo Nakanishi, and Hiromu Ito
    Journal of Clinical and Experimental Medicine (IGAKU NO AYUMI), 289 (4), 271-274 (2024).
    Released on April 27, 2024
  3. Analysis of a Planar Catechin Analog on Cancer Cellular Inhibition
    Hiromu Ito, Yoshimi Shoji, Ken-ichiro Matsumoto, Kiyoshi Fukuhara, and Ikuo Nakanishi
    Free Radical Biol. Med., 208 (Supplement 1), S124-S125 (2023).
    DOI: 10.1016/j.freeradbiomed.2023.10.283
    Released on November 1, 2023
  4. pH Effect on the Kinetic Isotope Effect in the Hydrogen Transfer from Trolox to Water-Solubilized 2,2-Diphenyl-1-picrylhydrazyl Radical in Phosphate Buffer Solutions
    Ikuo Nakanishi, Yoshimi Shoji, and Kei Ohkubo
    Free Radical Biol. Med., 192 (Supplement 1), 131 (2022).
    DOI: 10.1016/j.freeradbiomed.2022.10.243
    Released on November 1, 2022
  5. Evaluation of Redox Responses of Mouse Colorectum Tissue after X-ray Irradiation
    Megumi Ueno, Raj Kumar Parajuli, Hiromu Ito, Megumi Iiyama, Saaya Suzuki, Ken-ichiro Matsumoto, Ikuo Nakanishi, Ichio Aoki, and Akira Sumiyoshi
    Free Radical Biol. Med., 192 (Supplement 1), 128-129 (2022).
    DOI: 10.1016/j.freeradbiomed.2022.10.238
    Released on November 1, 2022
  6. Adjunctive Effects with Continual X-ray Irradiation for Effective Photodynamic Therapy
    Hiromu Ito and Ikuo Nakanishi
    Free Radical Biol. Med., 192 (Supplement 1), 125 (2022).
    DOI: 10.1016/j.freeradbiomed.2022.10.231
    Released on November 1, 2022
  7. pH Effect on the Scavenging Reaction of Ascorbic Acid against Selected Radicals in Phosphate Buffer Solutions
    Ikuo Nakanishi, Yoshimi Shoji, Kei Ohkubo, Toshihiko Ozawa, Ken-ichiro Matsumoto, and Shunichi Fukuzumi
    Free Radical Biol. Med., 180 (Supplement 1), S64 (2022).
    DOI: 10.1016/j.freeradbiomed.2021.12.146
    Released on February 20, 2022
  8. Initial Molecular Geometry of Radiation-Induced Reactive Species in Water
    Ken-ichiro Matsumoto, Megumi Ueno, Yoshimi Shoji, and Ikuo Nakanishi
    Free Radical Biol. Med., 180 (Supplement 1), S63-S64 (2022).
    DOI: 10.1016/j.freeradbiomed.2021.12.145
    Released on February 20, 2022