December 2025

横浜薬科大学の加藤真介教授が、大学院生の新田友香さんとともに来訪されました。
関連研究に関する情報交換を行った後、研究施設をご見学いただきました。
ご来訪いただき、誠にありがとうございました。

Professor Shinsuke Katoh from Yokohama University of Pharmacy visited us together with graduate student Yuka Nitta.
After exchanging information related to our ongoing research, we gave them a tour of our research facilities.
Thank you very much for your visit!

2026年度
  1. 【ポスター】An Approach for Estimating Radio-Biological Effects in Tissues Based on Tissue Oxygen Level-Dependent MRI and Redox Imaging
    上野恵美，髙　山，佐野ひろみ，パラジュリ・ラジュ・クマル，飯山　恵，荘司好美，伊藤　紘，中西郁夫，長田健介，小畠隆行，青木伊知男，住吉　晃，○松本謙一郎
    2026 ISMRM & ISMRT Annual Meeting & Exhibition，ケープタウン，2026年5月9〜14日

2025年度
  1. 【口頭】抗酸化物質のラジカル消去反応に対する水および重水の影響
    Effects of H2O and D2O on the Radical-Scavenging Reactions of Antioxidants
    荘司好美，大久保　敬，伊藤　紘，寺嶋友里，○中西郁夫
    日本薬学会第146年会，大阪，2026年3月26〜29日
  2. 【口頭】水溶性2-テトラゼンラジカルカチオン塩を用いる抗酸化物質活性評価法の開発
    Development of an Antioxidant Activity Assay Employing a Water-Soluble 2-Tetrazene Radical Cation Salt
    ○大城彩里，荘司好美，伊藤　紘，寺嶋友里，岩渕好治，中西郁夫，笹野裕介
    日本薬学会第146年会，大阪，2026年3月26〜29日
  3. 【ポスター】マウスの脳および直腸・結腸におけるX線照射後の組織の機能変化のMRIによる評価
    Estimation of Effects of X-ray Irradiation on Functions in Mouse Brain and Colorectum Tissues Using MRI
    ○上野恵美，髙　山，佐野ひろみ，パラジュリ・ラジュ・クマル，飯山　恵，荘司好美，伊藤　紘，中西郁夫，長田健介，小畠隆行，青木伊知男，住吉　晃，松本謙一郎
    日本薬学会第146年会，大阪，2026年3月26〜29日
  4. 【口頭】Pulsed EPR Spectroscopic Study on the Kinetics of Photo-Generated Free Radical Reactions
    ○河合明雄，中西郁夫，三宅祐輔，加藤将利
    18th DAE-BRNS Biennial Trombay Symposium on Radiation & Photochemistry (TSRP-2026)，ムンバイ，2026年1月6〜10日
  5. 【招待】カテキンの平面構造化による抗酸化能力増強と癌細胞傷害活性
    ○伊藤　紘
    大隈ライフサイエンス研究会 第14回シンポジウム，横浜，2025年12月10日
    伊藤紘主任研究員が大隈ライフサイエンス研究会奨励賞受賞！！
  6. 【ポスター】日本が先行してきた酸化ストレス研究と高機能ラジカル捕捉薬
    ○上林將人，中西郁夫，森川敏生，松田久司
    第35回日本循環薬理学会，米子，2025年12月5, 6日(5日, P8)
  7. 【招待】Elementary Reaction Rate Constants of Free Radicals Measured by Spin Echo Observation Using Pulsed ESR Spectroscopy
    平野弘樹，加藤将利，丸茂海斗，高橋広奈，三宅祐輔，中西郁夫，○河合明雄
    第64回電子スピンサイエンス学会年会(SEST2025)，桐生，2025年11月21日〜23日(22日, 2S-01)
  8. 【ポスター】三重項状態アントラキノンスルホン酸誘導体のラジカル消光過程に伴う電子スピン分極の定量評価と生成機構解明
    Quantitative Determination and Elucidation of the Mechanism of Dynamic Electron Spin Polarization Created by Radical Quenching Process of Triplet State Anthraquinone Sulfuric Acid Derivative
    ○上加あさぎ，加藤将利，中西郁夫，河合明雄
    第64回電子スピンサイエンス学会年会(SEST2025)，桐生，2025年11月21日〜23日(21日, P-44)
  9. 【ポスター】時間分解ESR法とパルスESR法を用いたベンジルドデシルトリチオカルボナートとアルカン系ラジカルの反応中間体観測と速度定数決定
    Observation of Reaction Intermediates and Determination of Rate Constants for the Reaction between Benzyl Dodecyl Carbonotrithioate and Alkyl Radicals Using Time-Resolved ESR and Pulsed ESR
    ○加藤将利，稲葉　喬，川井葉子，三宅祐輔，中西郁夫，河合明雄
    第64回電子スピンサイエンス学会年会(SEST2025)，桐生，2025年11月21日〜23日(21日, P-13)
  10. 【口頭】放射線が油脂中に⽣成する脂質フリーラジカルのEPR スピントラッピング法による定量
    上野恵美，荘司好美，古場裕介，孫　略，伊藤　紘，中西郁夫，○松本謙一郎
    第62回放射線影響懇話会，鹿児島，2025年10月4日
  11. 【招待】天然仏由来抗酸化物質の誘導体による癌細胞傷害活性－カテキン誘導体を中心に－
    ○伊藤　紘
    第69回日本薬学会関東支部大会，埼玉，2025年9月13日
  12. 【ポスター】パルスESR法を用いたヒドロキシアルカン系ラジカルの2,2'-[チオカルボニルビス(スルファンジイル)]ジプロピオン酸への付加反応観測
    ○加藤将利，稲葉　喬，川井葉子，三宅祐輔，中西郁夫，河合明雄
    第19回分子科学討論会，広島，2025年9月9日〜12日(11日, 3P057)
  13. 【ポスター】光分解生成ラジカルと2,2'-[チオカルボニルビス(スルファンジイル)]ジプロピオン酸のレーザー同期パルスESR法による反応速度定数決定
    Reaction Rate Constants of Photolysis Product Radicals with 2,2'-[Thiocarbonylbis(sulfanediyl)]dipropionic Acid Determined by Laser-Synchronized Pulsed-ESR Method
    ○加藤将利，稲葉　喬，川井葉子，三宅祐輔，中西郁夫，河合明雄
    2025年光化学討論会，東京，2025年9月4日〜6日(6日, 3P07)
  14. 【講義】天然抗酸化物質のラジカル消去機構解明と抗酸化医薬品開発のための基礎研究
    ○中西郁夫
    フリーラジカルスクール2025，和歌山，2025年8月7, 8日(8日, 講義10)
  15. 【ポスター】ニトロキシドラジカルと光励起アントラキノン誘導体の系で発生する電子スピン分極の時間分解ESR観測
    ○上加あさぎ，中西郁夫，河合明雄
    フリーラジカルスクール2025，和歌山，2025年8月7, 8日(7日, P-03)
    上加あさぎ実習生が優秀ポスター発表賞受賞！！
  16. 【ポスター】レーザー同期パルスESR法によるα-Tocopherolと光分解生成ラジカルの反応速度定数決定
    ○加藤将利，丸茂海斗，平野弘樹，中西郁夫，河合明雄
    フリーラジカルスクール2025，和歌山，2025年8月7, 8日(7日, P-02)
    加藤将利実習生が優秀ポスター発表賞受賞！！
  17. 【口頭】新規水溶性ラジカルカチオン塩を利用した抗酸化物質活性評価法の開発
    ○大城彩里，荘司好美，伊藤　紘，寺嶋友里，岩渕好治，中西郁夫，笹野裕介
    フリーラジカルスクール2025，和歌山，2025年8月7, 8日(7日, O-12)
    大城彩里実習生が優秀口頭発表賞受賞！！
  18. 【ポスター】ESRによる高分子酸化防止剤の検討
    ○中井由実，水田幸男，柳澤　匠，熊谷将吾，大久保　敬，中西郁夫
    第28回ESRフォーラム研究会，佐賀，2025年7月19日(P11)
  19. 【ポスター】Enhanced Cytotoxic Effect and Radical-Scavenging Activity of a Planar Catechin Analog Conjugated with Teprenone
    ○伊藤　紘，荘司好美，清水稚菜，上野恵美，松本謙一郎，福原　潔，中西郁夫
    22nd SFRRI Biennial Meeting，アイルランド，2025年6月3日〜6日(4日, PP II_C10)
    伊藤紘主任研究員がSFRR Japan Young Investigator Award 2025受賞
  20. 【ポスター】カテキンの平面構造化によるラジカル消去活性増強と癌細胞傷害効果
    ○伊藤　紘，荘司好美，清水稚菜，板橋勇輝，寒水壽朗，松本謙一郎，大久保　敬，福原　潔，中西郁夫
    量子生命科学会第7回大会，仙台，2025年5月28日〜30日(28日, P-63)
  21. 【ポスター】抗酸化物質のラジカル消去反応における速度論的同位体効果に対する溶媒の影響
    ○中西郁夫，荘司好美，清水稚菜，寺嶋友里，大久保　敬，伊藤　紘，丸山耕一，福原　潔，福住俊一
    量子生命科学会第7回大会，仙台，2025年5月28日〜30日(28日, P-62)
  22. 【口頭】炭素線照射した脂質中に生成するフリーラジカルの検出とその反応解析
    Detection of Lipid Free Radicals Induced by Carbon-Ion Beam Irradiation to Oil/Lipid
    ○上野恵美，荘司好美，伊藤　紘，中西郁夫，松本謙一郎
    2024年度HIMAC共同利用研究成果発表会，オンライン，2025年5月26, 27日(27日, 22H426)
  23. 【ポスター】パルスESR法によるα-tocopherolと有機ラジカルの反応中間体観測と速度定数決定
    ○加藤将利，丸茂海斗，平野弘樹，中西郁夫，河合明雄
    第78回日本酸化ストレス学会学術集会，小田原，2025年5月22日〜24日(22日, O-P4-6)
  24. 【ポスター】X線および重粒子（炭素）線がコーン油中に生成する脂質フリーラジカルの定量と局所生成濃度の評価
    ○上野恵美，荘司好美，伊藤　紘，中西郁夫，松本謙一郎
    第78回日本酸化ストレス学会学術集会，小田原，2025年5月22日〜24日(22日, O-P4-5)
  25. 【口頭】テプレノン付加による平面型カテキン誘導体の細胞傷害性増強効果
    ○伊藤　紘、荘司好美、清水稚菜、上野恵美、松本謙一郎、福原　潔、中西郁夫
    第78回日本酸化ストレス学会学術集会，小田原，2025年5月22日〜24日(22日, O-03-3)
  26. 【招待】カテキン誘導体の抗酸化効果と癌細胞への影響
    ○伊藤　紘
    科学的根拠に基づく健康寿命を伸ばす会(PH会)第32回講演会，東京，2025年5月15日

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以前の成果はresearchmapをご覧ください。
Dr. Hiromu Ito - https://researchmap.jp/hiromuito/
Dr. Ikuo Nakanishi - https://researchmap.jp/ikuo/

原著論文/Original Papers
  1. Title
    Hiroko P. Indo, Hiromu Ito, Motoki Imai, Fumitaka Kawakami, Makoto Kubo, Takafumi Ichikawa, Hiroshi Abe, Ikuo Nakanishi, Ken-ichiro Matsumoto, Suriyan Sukati, Jirapat Namkeaw, Thiranut Jaroonwitchawan, Voravuth Somsak, Jun Urano, and Hideyuki J. Majima*
    Mitochondrion, in preparation.
    DOI:
    PMID:
    Released on
  2. Title
    Hiroko P. Indo, Hiroshi Abe, Hiromu Ito, Ikuo Nakanishi, Ken-ichiro Matsumoto, Jun Urano, Suriyan　Sukati, Rachasak Boonhok, Moragot Chatatikun, Jitbanjong Tangpong, Voravuth Somsak, and Hideyuki J. Majima*
    Mitochondrion, in preparation.
    DOI:
    PMID:
    Released on
  3. Title
    Hiromu Ito, Yoshimi Shoji, Wakana Shimizu, Megumi Ueno, Ken-ichiro Matsumoto, Kei Ohkubo, Kiyoshi Fukuhara, and Ikuo Nakanishi
    Journal Title, in contribution.
    DOI:
    PMID:
    Released on
  4. Title
    Megumi Ueno, Minako Nyui, Ken-ichiro Matsumoto,* Ikuo Nakanishi, Hiroshi Abe, Hiroko P. Indo,* Akira Fujii, Masanobu Nagano, Jitbanjong Tangpong, and Hideyuki J. Majima*
    J. Food Sci., under revision.
    DOI:
    PMID:
    Released on
  5. Heme–Porphyrin Metabolism in Photodynamic Therapy Associated with Reactive Oxygen Species
    Hirofumi Matsui* and Hiromu Ito*
    J. Clin. Biochem. Nutr., in press.
    DOI: 10.3164/jcbn.25-181
    PMID:
    Released on November 15, 2025
  6. Laser-Synchronized Time-Resolved ESR Spectroscopy on the Elementary Process of the Radical Addition Reaction to the C=S Double Bond
    Masatoshi Kato, Takashi Inaga, Yoko Kawai, Yusuke Miyake, Ikuo Nakanishi, and Akio Kawai*
    Sci. J. Kanagawa Univ., 36, 33-38 (2025).
    DOI: 10.24792/0002001841
    Released on July 31, 2025
  7. Enhanced Cytotoxicity against Cancer Cells by Acetylation of a Planar Catechin Analog
    Hiromu Ito,* Yoshimi Shoji, Yuki Itabashi, Ken-ichiro Matsumoto, Kei Ohkubo,* Kiyoshi Fukuhara,* and Ikuo Nakanishi*
    Free Radical Res., 59 (6-7), 480-486 (2025).
    DOI: 10.1080/10715762.2025.2525185
    PMID: 40571429
    Released on July 4, 2025
  8. Radical Scavenging Rate Constants Determined by Spin Relaxation Times of Spin Polarized Radicals as Measured by Free Induction Decay Signals
    Hiroki Hirano, Ai Nagata, Kaito Marumo, Hirona Takahashi, Ikuo Nakanishi, and Akio Kawai*
    J. Chem. Phys., 162, 124707 (2025).
    DOI: 10.1063/5.0251604
    PMID: 40125680
    Released on March 24, 2025
    1855373_1_unknown_upload_25037618_sr939k
  9. Synephrine Inhibits Oxidative Stress and H2O2-Induced Premature Senescence
    Hiroshi Abe, Hiroko P. Indo,* Hiromu Ito, Hideyuki J. Majima, and Tatsuro Tanaka
    Cell Biochem. Biophys., 83 (2), 2607-2622 (2025). Open access
    DOI: 10.1007/s12013-025-01669-7
    PMID: 39832117
    Released on January 20, 2025
  10. The Roles of Mitochondria in Human Being's Life and Aging
    Hiroko P. Indo, Moragot Chatatikun, Ikuo Nakanishi, Ken-ichiro Matsumoto, Motoki Imai, Fumitaka Kawakami, Makoto Kubo, Hiroshi Abe, Hiroshi Ichikawa, Yoshikazu Yonei, Hisashi J. Beppu, Yukiko Minamiyama, Takuro Kanekura, Takafumi Ichikawa, Atthaphong Phongphithakchai, Lunla Udomwech, Suriyan Sukati, Nurdina Charong, Voravuth Somsak, Jitbanjong Tangpong, Sachiyo Nomura, and Hideyuki J. Majima*
    Biomolecules, 14 (10), 1317 (2024). Open access
    DOI: 10.3390/biom14101317
    PMID: 39456251
    Released on October 17, 2024
    biomolecules-14-01317-ag
  11. Antioxidant Activity of Planar Catechin Conjugated with Trolox
    Wakana Shimizu, Yoshimi Shoji, Kei Ohkubo, Hiromu Ito, Ikuo Nakanishi,* and Kiyoshi Fukuhara*
    Antioxidants, 13 (10), 1165 (2024). Open access
    DOI: 10.3390/antiox13101165
    PMID: 39456420
    Released on September 25, 2024
    PCat-TrOH_Antioxidants_GA
  12. A Mechanism for Apoptotic Effects of a Planar Catechin Analog on Cancer Cells
    Hiromu Ito,* Yoshimi Shoji, Ken-ichiro Matsumoto, Kiyoshi Fukuhara, and Ikuo Nakanishi*
    Molecules, 29 (18), 4467 (2024). Open access
    DOI: 10.3390/molecules29184467
    PMID: 39339462
    Released on September 20, 2024
  13. Construction of a Screening System for Lipid-Derived Radical Inhibitors and Validation of Hit Compounds to Target Retinal and Cerebrovascular Diseases
    Ryota Mori, Masami Abe, Yuma Saimoto, Saki Shinto, Sara Jodai, Manami Tomomatsu, Kaho Tazoe, Minato Ishida, Masataka Enoki, Nao Kato, Tomohiro Yamashita, Yuki Itabashi, Ikuo Nakanishi, Kei Ohkubo, Sachiko Kaidzu, Masaki Tanito, Yuta Matsuoka, Kazushi Morimoto, and Ken-ichi Yamada*
    Redox Biol., 73, 103186 (2024). Open access
    DOI: 10.1016/j.redox.2024.103186
    PMID: 38744193
    Released on May 8, 2024
  14. Scandium Ion-Promoted Electron-Transfer Disproportionation of 2-Phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl 3-Oxide (PTIO center dot) in Acetonitrile and Its Regeneration Induced by Water
    Yoshimi Shoji, Yuri Terashima, Kei Ohkubo, Hiromu Ito, Kouichi Maruyama, Shunichi Fukuzumi, and Ikuo Nakanishi*
    Int. J. Mol. Sci., 25 (8), 4417 (2024). Open access
    DOI: 10.3390/ijms25084417
    PMID: 38674002
    Released on April 17, 2024
    IJSM2024_25_4417
  15. Reactive Oxygen Species Induced by Indomethacin Enhance Accumulation of Heme Carrier Protein 1 and Hematoporphyrin Accumulation In Vitro and In Vivo in a Brain Tumor Model
    Hidehiro Kohzuki, Hiromu Ito, Hiromi Kurokawa, Hirofumi Matsui,* Tetsuya Yamamoto, and Eiichi Ishikawa
    J. Clin. Biochem. Nutr., 74 (3), 207-212 (2024) Open access
    DOI: 10.3164/jcbn.23-20
    PMID: 38799142
    Released on February 1, 2024
  16. Mitochondria Play Essential Roles in Intracellular Protection against Oxidative Stress—Which Molecules among the ROS Generated in the Mitochondria Can Escape the Mitochondria and Contribute to Signal Activation in Cytosol?
    Daisuke Masuda, Ikuo Nakanishi,* Kei Ohkubo, Hiromu Ito, Ken-ichiro Matsumoto, Hiroshi Ichikawa, Moragot Chatatikun, Wiyada Kwanhian Klangbud, Manas Kotepui, Motoki Imai, Fumitaka Kawakami, Makoto Kubo, Hirofumi Matsui, Jitbanjong Tangpong, Takafumi Ichikawa, Toshihiko Ozawa, Hsui-Chuan Yen, Daret K. St Clair, Hiroko P. Indo,* and Hideyuki J. Majima*
    Biomolecules, 14 (1), 128 (2024). Open access
    DOI: 10.3390/biom14010128
    PMID: 38275757
    Released on January 19, 2024
  17. Hair Follicle Damage after 100 mGy Low-Dose Fractionated X-ray Irradiation and the Protective Effects of TEMPOL, a Stable Nitroxide Radical, against Radiation
    Yoshihiro Kawabata, Tomoko Fukushige, Hiroko P. Indo, Ken-ichiro Matsumoto,* Megumi Ueno, Ikuo Nakanishi, Moragot Chatatikun, Wiyada Kwanhian Klangbud, Sirirat Surinkaew, Jitbanjong Tangpong, Takuro Kanekura, and Hideyuki J. Majima*
    Radiat. Res., 201 (2), 115-125 (2024).
    DOI: 10.1667/RADE-23-00167.1
    PMID: 38211765
    Released on January 12, 2024
  18. Enhanced Inhibition of Cancer Cell Migration by a Planar Catechin Analog
    Hiromu Ito,* Yoshimi Shoji, Ken-ichiro Matsumoto, Kiyoshi Fukuhara,* and Ikuo Nakanishi*
    ACS Med. Chem. Lett., 15 (2), 310-313 (2024).
    DOI: 10.1021/acsmedchemlett.3c00499
    PMID: 38352823
    Released on January 10, 2024
    images_medium_ml3c00499_0003s
  19. Photodynamic Therapy for X-ray-Induced Radiation-Resistant Cancer Cells
    Hiromu Ito,* Yoshimi Shoji, Megumi Ueno, Ken-ichiro Matsumoto, and Ikuo Nakanishi*
    Pharmaceutics, 15 (11), 2536 (2023). Open access
    DOI: 10.3390/pharmaceutics15112536
    PMID: 38004516
    Released on October 26, 2023
    pharmaceutics-15-02536-ag_s
  20. Enhancement of Cytotoxic Effects with ALA-PDT on Treatment of Radioresistant Cancer Cells
    Takafumi Ikeda, Hiromi Kurokawa,* Hiromu Ito,* Kiichiro Tsuchiya, and Hirofumi Matsui*
    J. Clin. Biochem. Nutr., 74 (1), 17-21 (2024). Open access
    DOI: 10.3164/jcbn.23-79
    PMID: 38292126
    Released on October 3, 2023
  21. Anti-Cancer Effect of a Planar Catechin Analog through the Decrease in Mitochondrial Membrane Potential
    Hiromu Ito,* Yoshimi Shoji, Ken-ichiro Matsumoto, Kiyoshi Fukuhara,* and Ikuo Nakanishi*
    ACS Med. Chem. Lett., 14 (10), 1478-1481 (2023).
    DOI: 10.1021/acsmedchemlett.3c00328
    PMID: 37849552
    Released on October 3, 2023
    images_large_ml3c00328_0004_480
  22. Water-Induced Regeneration of a 2,2-Diphenyl-1-picrylhydrazyl Radical after Its Scandium Ion-Promoted Electron-Transfer Disproportionation in an Aprotic Medium
    Ikuo Nakanishi,* Yoshimi Shoji, Kei Ohkubo,* Hiromu Ito, and Shunichi Fukuzumi*
    Molecules, 28 (13), 5002 (2023). Open access
    DOI: 10.3390/molecules28135002
    PMID: 37446663
    Released on June 26, 2023
    GA_v2_
  23. In Vitro Radical-Scavenging Mechanism of Melatonin and Its In Vivo Protective Effect against Radiation-Induced Lipid Peroxidation
    Kailash Manda,* Kei Ohkubo,* Yoshimi Shoji, A. K. M. Raushan Kabir Zoardar, Masato Kamibayashi, Toshihiko Ozawa, Kazunori Anzai, and Ikuo Nakanishi*
    Redox Biochem. Chem., 3-4, 100003 (2023). Open access
    DOI: 10.1016/j.rbc.2023.100003
    Released on April 11, 2023
  24. Effects of X-ray Irradiation on the Redox Status of Mouse Colorectal Tissues
    Megumi Ueno, Raj Kumar Parajuri, Hiromu Ito, Megumi Iiyama, Saaya Suzuki, Ken-ichiro Matsumoto,* Ikuo Nakanishi, Ichio Aoki, and Akira Sumiyoshi
    Adv. Redox Res., 8, 100067 (2023). Open access
    DOI: 10.1016/j.arres.2023.100067
    Released on March 26, 2023
  25. Evidence of Nrf2/Keap1 Signaling Regulation by Mitochondria-Generated Reactive Oxygen Species in RGK1 Cells
    Hiroko P. Indo,* Daisuke Masuda, Sompong Srburee, Hiromu Ito, Ikuo Nakanishi, Ken-ichiro Matsumoto, Samlee Mankhetkorn, Moragot Chatatikun, Sirirat Surinkaew, Lunla Udomwech, Fumitaka Kawami, Takafumi Ichikawa, Hirofumi Matsui, Jitbanjong Tangpong, and Hideyuki J. Majima*
    Biomolecules, 13 (3), 445 (2023). Open access
    DOI: 10.3390/biom13030445
    PMID: 36979380
    Released on February 27, 2023
    biomolecules-13-00445-ag_s
  26. DTPA-Bound Planar Catechin with Potent Antioxidant Activity Triggered by Fe3+ Coordination
    Kiyoshi Fukuhara,* Ikuo Nakanishi, Kohei Imai, Mirei Mizuno, Ken-ichiro Matsumoto, and Akiko Ohno
    Antioxidants, 12 (2), 225 (2023). Open access
    DOI: 10.3390/antiox12020225
    PMID: 36829782
    Released on January 18, 2023
    antioxidants-12-00225-ag-480
  27. Effects of Selenium Deficiency on Biological Results of X-ray and Carbon-Ion Beam Irradiation in Mice
    Megumi Ueno, Sayaka Shibata, Ikuo Nakanishi, Ichio Aoki, Ken-ichi Yamada, and Ken-ichiro Matsumoto*
    J. Clin. Biochem. Nutr., 72 (2), 107-116 (2023). Open access
    DOI: 10.3164/jcbn.22-57
    PMID: 36936873
    Released on December 8, 2022
  28. Acetic Acid Enhances the Effect of Photodynamic Therapy in Gastric Cancer Cells via the Production of Reactive Oxygen Species
    Hiromi Kurokawa, Hiromu Ito, Daisuke Matano, Masahiko Terasaki, and Hirofumi Matsui*
    J. Clin. Biochem. Nutr., 71 (3) 206-211 (2022). Open access
    DOI: 10.3164/jcbn.22-34
    PMID: 36447491
    Released on August 4, 2022
  29. Importance of Locations of Iron Ions to Elicit Cytotoxicity Induced by a Fenton-Type Reaction
    Kintaro Igarashi, Yoshimi Shoji, Emiko Sekine-Suzuki, Megumi Ueno, Ken-ichiro Matsumoto,* Ikuo Nakanishi, and Koji Fukui
    Cancers, 14 (15), 3642 (2022). Open access
    DOI: 10.3390/cancers14153642
    PMID: 35892902
    Released on July 27, 2022
  30. Effect of Magnesium Ion on the Radical-Scavenging Rate of Pterostilbene in an Aprotic Medium: Mechanistic Insight into the Antioxidative Reaction of Pterostilbene
    Ikuo Nakanishi,* Yoshimi Shoji, Kei Ohkubo,* Megumi Ueno, Kei Shimoda, Ken-ichiro Matsumoto, Kiyoshi Fukuhara,* and Hiroki Hamada*
    Antioxidants, 11 (2), 340 (2022). Open access
    DOI: 10.3390/antiox11020340
    PMID: 35204222
    Released on February 9, 2022
    antioxidants-11-00340-ag_s
  31. Estimation of the Local Concentration of the Markedly Dense Hydroxyl Radical Generation Induced by X-rays in Water
    Ken-ichiro Matsumoto,* Megumi Ueno, Yoshimi Shoji, and Ikuo Nakanishi
    Molecules, 27 (3), 592 (2022). Open access
    DOI: 10.3390/molecules27030592
    PMID: 35163857
    Released on January 18, 2022
  32. Simplifying Quantitative Measurement of Free Radical Species Using an X-Band EPR Spectrometer
    Yusuke Makino, Megumi Ueno, Yoshimi Shoji, Minako Nyui, Ikuo Nakanishi, Koji Fukui, and Ken-ichiro Matsumoto*
    J. Clin. Biochem. Nutr., 70 (3), 213-221 (2022). Open access
    DOI: 10.3164/jcbn.21-83
    PMID: 35692674
    Released on December 25, 2021
  33. Electrochemical Redox Behavior of 2,2-Diphenyl-1-picrylhydrazyl Radical Solubilized by beta-Cyclodextrin in Water
    Ikuo Nakanishi* and Yoshimi Shoji
    Electrochem. Commun., 134, 107190 (2022). Open access
    DOI: 10.1016/j.elecom.2021.107190
    Released on December 24, 2021
    Electrochem_Commun360
  34. Tunneling in the Hydrogen-Transfer Reaction from a Vitamin E Analog to an Inclusion Complex of 2,2-Diphenyl-1-picrylhydrazyl Radical with beta-Cyclodextrin in an Aqueous Buffer Solution at Ambient Temperature
    Ikuo Nakanishi,* Yoshimi Shoji, Kei Ohkubo,* and Shunichi Fukuzumi*
    Antioxidants, 10 (12), 1966 (2021). Open access
    DOI: 10.3390/antiox10121966
    PMID: 34943069
    Released on December 8, 2021
  35. Effects of Loading a Magnetic Field Longitudinal to the LInear Particle-Beam Track on Yields of Reactive Oxygen Species in Water
    Ken-ichiro Matsumoto,* Ikuo Nakanishi, Yasushi Abe, Shinji Sato, Ryosuke Kohno, Dousatsu Sakata, Kota Mizushima, Sung Hyun Lee, and Taku Inaniwa
    Free Radical Res., 55 (5), 547-555 (2021). Open access
    DOI: 10.1080/10715762.2021.1970151
    PMID: 34569399
    Released on September 27, 2021
  36. Effects of LET on Oxygen-Dependent and -Independent Generation of Hydrogen Peroxide in Water Irradiated by Carbon-Ion Beams
    Ken-ichiro Matsumoto,* Megumi Ueno, Minako Nyui, Yoshimi Shoji, and Ikuo Nakanishi
    Free Radical Res., 55 (6), 589-594 (2021). Open access
    DOI: 10.1080/10715762.2021.1915489
    PMID: 34519601
    Released on September 14, 2021
  37. Nitroxyl Radical as a Theranostic Contrast Agent in Magnetic Resonance Imaging
    Ken-ichiro Matsumoto,* Ikuo Nakanishi, Zhivko Zhelev, Rumiana Bakalova, and Ichio Aoki
    Antioxid. Redox Signaling, 36 (1-3), 95-121 (2022). Open access
    DOI: 10.1089/ars.2021.0110
    PMID: 34148403
    Released on June 19, 2021
  38. Protective Effects of Amino Acids on Plasmid DNA Damage Induced by Therapeutic Carbon Ions
    Katsunori Yogo,* Chieko Murayama, Ryoichi Hirayama, Ken-ichiro Matsumoto, Ikuo Nakanishi, Hiromichi Ishiyama, and Hiroshi Yasuda
    Radiat. Res., 196 (2), 197-203 (2021).
    DOI: 10.1667/RADE-21-00033.1
    PMID: 34043797
    Released on May 27, 2021

プロシーディングなど/Proceedings, etc.
  1. Enhanced Cytotoxic Effect and Radical-Scavenging Activity of a Planar Catechin Analog Conjugated with Teprenone
    Hiromu Ito, Yoshimi Shoji, Wakana Shimizu, Megumi Ueno, Ken-ichiro Matsumoto, Kiyoshi Fukuhara, and Ikuo Nakanishi
    Free Radical Biol. Med., 233 (Supplement 1), S78-S79 (2025).
    DOI: 10.1016/j.freeradbiomed.2025.05.278
    Released on May 30, 2025
  2. Antioxidant Activity of Planar Catechin Conjugated with Trolox
    Wakana Shimizu, Yoshimi Shoji, Kei Ohkubo, Hiromu Ito, Ikuo Nakanishi,* and Kiyoshi Fukuhara*
    Preprints, 2024081751 (2024).
    DOI: 10.20944/preprints202408.1751.v1
    Released on August 23, 2024
  3. 放射線障害予防と酸化ストレス
    松本謙一郎，中西郁夫，伊藤　紘
    酸化ストレスの医学 改訂第3版, 一般社団法人日本酸化ストレス学会監修，内藤裕二，豊國伸哉，赤池孝章，半田修編，東京，診断と治療社，2024, p.500-506.
    Released on June 5, 2024
  4. Radiation Damage and Oxidative Stress
    Ken-ichiro Matsumoto, Ikuo Nakanishi, and Hiromu Ito
    Journal of Clinical and Experimental Medicine (IGAKU NO AYUMI), 289 (4), 271-274 (2024).
    Released on April 27, 2024
  5. Analysis of a Planar Catechin Analog on Cancer Cellular Inhibition
    Hiromu Ito, Yoshimi Shoji, Ken-ichiro Matsumoto, Kiyoshi Fukuhara, and Ikuo Nakanishi
    Free Radical Biol. Med., 208 (Supplement 1), S124-S125 (2023).
    DOI: 10.1016/j.freeradbiomed.2023.10.283
    Released on November 1, 2023
  6. pH Effect on the Kinetic Isotope Effect in the Hydrogen Transfer from Trolox to Water-Solubilized 2,2-Diphenyl-1-picrylhydrazyl Radical in Phosphate Buffer Solutions
    Ikuo Nakanishi, Yoshimi Shoji, and Kei Ohkubo
    Free Radical Biol. Med., 192 (Supplement 1), 131 (2022).
    DOI: 10.1016/j.freeradbiomed.2022.10.243
    Released on November 1, 2022
  7. Evaluation of Redox Responses of Mouse Colorectum Tissue after X-ray Irradiation
    Megumi Ueno, Raj Kumar Parajuli, Hiromu Ito, Megumi Iiyama, Saaya Suzuki, Ken-ichiro Matsumoto, Ikuo Nakanishi, Ichio Aoki, and Akira Sumiyoshi
    Free Radical Biol. Med., 192 (Supplement 1), 128-129 (2022).
    DOI: 10.1016/j.freeradbiomed.2022.10.238
    Released on November 1, 2022
  8. Adjunctive Effects with Continual X-ray Irradiation for Effective Photodynamic Therapy
    Hiromu Ito and Ikuo Nakanishi
    Free Radical Biol. Med., 192 (Supplement 1), 125 (2022).
    DOI: 10.1016/j.freeradbiomed.2022.10.231
    Released on November 1, 2022
  9. On 'Spin Trapping of Superoxide and Hydroxyl Radical: Practical Aspect' by Eli Finkelstein, Gerald M. Rosen and Elmer J. Rauckman
    Toshihiko Ozawa* and Ikuo Nakanishi
    Arch. Biochem. Biophys., 726, 109191 (2022).
    DOI: 10.1016/j.abb.2022.109191
    PMID: 35318035
    Released on March 19, 2022
  10. pH Effect on the Scavenging Reaction of Ascorbic Acid against Selected Radicals in Phosphate Buffer Solutions
    Ikuo Nakanishi, Yoshimi Shoji, Kei Ohkubo, Toshihiko Ozawa, Ken-ichiro Matsumoto, and Shunichi Fukuzumi
    Free Radical Biol. Med., 180 (Supplement 1), S64 (2022).
    DOI: 10.1016/j.freeradbiomed.2021.12.146
    Released on February 20, 2022
  11. Initial Molecular Geometry of Radiation-Induced Reactive Species in Water
    Ken-ichiro Matsumoto, Megumi Ueno, Yoshimi Shoji, and Ikuo Nakanishi
    Free Radical Biol. Med., 180 (Supplement 1), S63-S64 (2022).
    DOI: 10.1016/j.freeradbiomed.2021.12.145
    Released on February 20, 2022
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